ChemInform Abstract: Synthesis and Quantitative Structure‐Activity Relationships of Antiallergic 2‐Hydroxy‐N‐1H‐tetrazol‐S‐ylbenzamides and N‐(2‐Hydroxyphenyl)‐1H‐tetrazole‐5‐carboxamides.

Abstract

5‐Aminotetrazol (I) wird mit den substituierten Salicylsäuren (II) zu den Amiden (III) umgesetzt.

Isomerization of Allylbenzenes

“…In the early 1970s, Golborn and Sheinmann observed that treatment of 2-allylphenol 158e and eugenol 5 with this catalyst in benzene under reflux facilitated quantitative isomerization of the allyl groups, predominantly to the trans -isomers 159e and 18 , respectively . Other researchers have also used this particular catalyst to effectively isomerize arylallyl compounds. − To demonstrate the applicability of the PdCl 2 (PhCN) 2 method, Ford et al isomerized 1-(3-allyl-2-hydroxyphenyl)­ethanone 351 on a 100 g scale with this catalyst to afford 352 . The isomerization was followed by an ozonolysis to afford 3-formyl-2-hydroxyacetophenone, and an oxidation with silver­(I) oxide then afforded the corresponding carboxylic acid 353 (Scheme ).…”

“…The isomerization was followed by an ozonolysis to afford 3-formyl-2-hydroxyacetophenone, and an oxidation with silver­(I) oxide then afforded the corresponding carboxylic acid 353 (Scheme ). This particular compound was then used for the synthesis of a series of antiallergics . Another interesting isomerization application of PdCl 2 (PhCN) 2 was described by Ferreira and co-workers, who obtained compound 354 in almost quantitative yield from the corresponding allyl-containing substrate (conditions: benzene, heat) .…”

“…This particular compound was then used for the synthesis of a series of antiallergics. 461 Another interesting isomerization application of PdCl 2 (PhCN) 2 was described by Ferreira and coworkers, who obtained compound 354 in almost quantitative yield from the corresponding allyl-containing substrate (conditions: benzene, heat). 463 This compound was further extrapolated into a number of isoflavonoid−neoflavonoid dimers of the daljanelin class.…”