ChemInform Abstract: SYNTHESIS AND PREGNANCY TERMINATING ACTIVITY OF 2‐ARYLIMIDAZO(2,1‐A)ISOQUINOLINES AND ISOINDOLES

Abstract

Die Phenacylbromide (I) reagieren mit dem 1‐Aminoisochinolin (II) in Gegenwart von Basen zu den Arylimidazoisochinolinen (III), die auch aus Isochinolin (V) und (I) über die Phenacylisochinoliniumbromide (IV) mit FeCl3/NH3 zugänglich sind.

Imidazo‐Fused Isoindoles by Pd(II)/Ag(I)‐Promoted Intramolecular Dehydrogenative Coupling

“…The crude reaction product obtained by Pd‐catalyzed intramolecular CDC of 1‐benzyl‐4‐phenyl‐1 H ‐imidazole ( 1l ) was purified by flash chromatography on silica gel with a mixture of DCM and MeOH (93:7) as eluent, followed by crystallization from CHCl 3 /hexane to give 2l as a pale beige solid (119 mg, 50 % yield): ): m.p. 190–192 °C (Lit[11f] 172–175 °C; Lit 152–153 °C). GLC analysis showed that 2l had chemical purity higher than 98 %.…”

Use of Ionic Liquids as Neoteric Solvents in the Synthesis of Fused Heterocycles

“…Imidazo[2,1‐ a ]isoquinolines are of interest due to their anti‐inflammatory potential , antirhinoviral , long‐acting local anesthetic properties , and as antiulcer agents . Hou et al used ionic liquid for the synthesis of imidazo[2,1‐ a ]isoquinolines 19 by stirring a mixture of α‐tosyloxyacetophenone 17 , 1‐aminoisoquinoline 18 , and Na 2 CO 3 in BPyBF 4 (Scheme ).…”

Synthesis, Autoorganization and Reactivity of Amphiphilic Derivatives of 1‐Aminoisoindole in Water and Formamide

“…Isoindoles are promising active biological materials [1,2] with interesting spectral properties and are the subject of studies for important theoretical questions, such as: aromaticity, tautomerism [3][4][5][6][7] and represent an important source of reagents used in cycloaddition reactions, [8][9][10][11][12] the study of organic reaction mechanisms, new rearrangements [13,14].…”