ChemInform Abstract: Synthesis and Pharmacological Profile of Two Novel Heterocyclic Chromanols, CP‐80,798 and CP‐85,958, as Potent LTD4 Receptor Antagonists.
Abstract:Synthesis and Pharmacological Profile of Two Novel Heterocyclic Chromanols, 958, as Potent LTD4 Receptor Antagonists.-A straightforward synthesis of the novel chromanols CP-80,798 (-)-( VIIIa), a balanced 5-lipoxygenase inhibitor/leukotriene D4 (LTD4) antagonist, and CP-85,958 (IX), a potent and selective LTD4-antagonist, starting from commercially available chromanone (I) is given. The optically pure chromanols, which are clinical candidates for the treatment of asthma, are obtained by resolution of the cor… Show more
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