ChemInform Abstract: Synthesis and in vitro Study of Novel Methylenebis(phenyl‐1,5‐benzothiazepine)s (III) and Methylenebis(benzofuryl‐1,5‐benzothiazepine)s (V) as Antimicrobial Agents.

Abstract

Synthesis and in vitro Study of Novel Methylenebis(phenyl-1,5-benzothiazepine)s (III) and Methylenebis(benzofuryl-1,5-benzothiazepine)s (V) as AntimicrobialAgents. -All compounds are tested for their antimicrobial and antifungal effects. Among them, derivatives (IIIf), (Ve) and (Vf) are found to be the most active ones against all the microorganisms. -(SANJEEVA REDDY*, C.; PURNACHANDRA REDDY, G.; NAGARAJ, A.; Chin.

2-(4-Fluorophenyl)-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine

“…For heterocycles containing the 1,4-thiazepine ring used as pharmaceutical agents as well as for biologically active compounds, see: Shi et al (2012). For the pharmacological activity of benzothiazepine and its derivatives, see: Sanjeeva et al (2008). For standard bond lengths, see: Allen et al (1987).…”

“…The title compound C 19 H 14 F N S 2 , (I), is a tetracyclic structure with one aromatic ring fused to a seven membered ring, on which two heteroatoms are present. Benzothiazepine and its derivatives show a wide spectrum of pharmacological activities such as antifeedent, coronary vasodilatory, tranquilizer, antidepressant, CNS stimulant, antihypertensive, calcium channel blocker, antiulcer, calcium antagonist and antimicrobial agents (Sanjeeva et al, 2008). The atoms C9, C8, C11 and C12 present in the central thiazepine ring forms a basal plane with S10 atom as the bow, representing the boat conformation of thiazepine ring.…”

2-(3,4-Dimethoxyphenyl)-4-(thiophen-2-yl)-2,3-dihydro-1,5-benzothiazepine

“…For the biological activity of benzophenone derivatives, see: Cutignano et al (2003); Sanjeeva et al (2008). For a related structure, see: Manjula et al (2013).…”

“…Heterocycles containing the 1,4-thiazepine ring is one of important moieties in nitrogen and sulfur containing heterocycles and has been widely used as key building block for pharmaceutical agents as well as biologically active compounds. Benzothiazepine and its derivatives show a wide spectrum of pharmacological activities such as antifeedent, coronary vasodilatory, tranquilizer, antidepressant, CNS stimulant, antihypertensive, calcium channel blocker, antiulcer, calcium antagonist and antimicrobial agents (Sanjeeva et al, 2008). The C6-N12 is shorter than an usual C-N single bond [1.294 Å compared to 1.416 Å] and the C10-S9 bond is shorter than an usual C-S single bond [1.760 Å compared to 1.82 Å].…”

Synthesis and Characterization of Some New 4,5-Dihydropyrazolyl Thiazoles

“…Thiosemicarbazide is one of the most important precursor for the formation of different acyclic 1 and cyclic organic compounds, especially heterocyclic compounds containing nitrogen and sulfur heteroatoms 2 . Chalcones also can be used as a very useful precursor besides thiosemicarbazide and other reagents for the formation of different important heterocyclic compounds such as pyrazolines 3 , thiadiazoles 4 and thiazepines 5 . Chalcones constitute a class of naturally occurring and synthetic compounds belonging to the flavonoid family 6 .…”