ChemInform Abstract: Synthesis and Immunostimulating Activity of New 1,4‐Benzothiazine Derivatives.

Abstract

Synthesis and Immunostimulating Activity of New 1,4-Benzothiazine Derivatives.-Title compounds such as (III) (11 examples) and (VI) are prepared and tested for their immunomodulating properties. All the products show activity in superoxide anion production by peritoneal macrophages in prednisolone-immunodepressed mice. The most interesting compounds ( IIIa), (IIIb) and (VI) are studied in comparison with standard ( Roquinimex) in the same test at lower dosages. The results show that ( IIIa) and (VI) are more active than Roquinimex. -(DEL CORONA, L.; SIGNORELLI, G.; PINZETTA, A.; COPPI, G.; Eur.

Synthesis and characterization of new thiourea and urea derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d] isoxazole: In vitro Antimicrobial and Antioxidant activity

“…3, 4 1,2-Benzisoxazoles substituted derivatives were used as anticonvulsant, 5,6 anti-psychotic, 7 anti-cancer, 8,9 antimicrobial, 10 anti-thrombotic, 11 uricosuric, 12 anti-inflammatory, 13 tuberculostatic, 14 sedative, 15 analgesic 16 and neuroleptic agents. 17 In addition, N-benzylpiperidinebenzisoxazole derivatives are selective inhibitors of the enzyme acetyl cholinesterase (AChE), used for the treatment of Alzheimer's disease. 18 Particularly, 3-(4piperidyl)-6-fluoro-1,2-benzisoxazole is an important intermediate for the synthesis of paliperidone which is the primary active metabolite of the older antipsychotic risperidone.…”