ChemInform Abstract: Synthesis and Evaluation of Phenyl‐Substituted Sydnones as Potential DPPH‐Radical Scavengers.

Mallur, Shanta G.; Tiwari, Ajay; Raju, B. China; Babu, K. Suresh; Ali, Amtul Z.; Sastry, B. S.; Rao, Madhusudana J.

doi:10.1002/chin.200804136

Cited by 2 publications

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“…Our data also corroborate the observation of Mallur et al . (2007) , who previously reported the ability of sydnones to scavenge free radicals in vitro . In our in vivo studies, a dual effect of Syd‐1 on GSH was observed.…”

Section: Discussionmentioning

confidence: 97%

Sydnone 1: A Mesoionic Compound with Antitumoral and Haematological Effects In Vivo

Galuppo

Lívero

Martins

et al. 2016

Basic Clin Pharma Tox

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This study evaluated the antitumour activity of the mesoionic compound sydnone 1 (Syd-1) against Walker-256 carcinosarcoma. Tumour cells were subcutaneously inoculated in the hind limb in male Wistar rats. The animals were orally treated for 12 days with Syd-1 (75 mg/kg) or vehicle. At the end of treatment, considerable decreases in tumour volume and tumour weight were observed in treated animals. Samples of these tumours presented increases in apoptotic bodies and pro-apoptotic protein expression (Bax and p53), while the expression of the anti-apoptotic protein Bcl-2 was reduced. A decrease in reduced glutathione levels and an increase in glutathione peroxidase activity were observed in tumour after Syd-1 treatment. However, significant splenomegaly was evident in animals that received Syd-1, most likely attributable to the induction of haemolysis. This study demonstrated the antitumour activity of Syd-1 against Walker-256 carcinosarcoma. Its mechanism of action is linked to the activation of apoptotic pathways that lead to tumour cell death.

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Section: Discussionmentioning

confidence: 97%

Sydnone 1: A Mesoionic Compound with Antitumoral and Haematological Effects In Vivo

Galuppo

Lívero

Martins

et al. 2016

Basic Clin Pharma Tox

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“…A large number of sydnone derivatives have been synthesized with biological interest [2][3][4][5] and reported to possess a wide spectrum of biological activities such as antiviral 6 , antimicrobial 7 , antiinflammatory 8 , analgesic 8 , anthelmintic 8 , antitumor 9 , free radical scavenging 10 and nitric oxide donor 11 activities. The potential value of sydnones as biologically active substances is found in their planar aromatic character, their relatively small size and variation in electron density around the ring.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Analgesic Activities of 4‐[1‐Oxo‐3‐(substituted aryl)‐2‐propenyl]‐3‐(4‐methylphenyl) sydnones

Deshpande¹,

Pai

2009

Journal of Chemistry

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A series of sydnone derivatives containing styryl ketone moiety, 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methylphenyl)sydnones (6a-i) has been synthesized and characterized by spectral data. The synthesized compounds have been screened for preliminary antibacterial activity by cup plate method and analgesic activity by the method of acetic acid induced writhing in mice. The chloro and nitro derivatives showed good antibacterial activity against both gram positive and gram negative bacteria while the chloro and furyl derivatives exhibited highest analgesic effect among the series.

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ChemInform Abstract: Synthesis and Evaluation of Phenyl‐Substituted Sydnones as Potential DPPH‐Radical Scavengers.

Cited by 2 publications

References 0 publications

Sydnone 1: A Mesoionic Compound with Antitumoral and Haematological Effects In Vivo

Sydnone 1: A Mesoionic Compound with Antitumoral and Haematological Effects In Vivo

Synthesis, Antibacterial and Analgesic Activities of 4‐[1‐Oxo‐3‐(substituted aryl)‐2‐propenyl]‐3‐(4‐methylphenyl) sydnones

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