“…Pyridopyrimidine derivatives are fused heterocyclic compounds which are known for their pharmacological and biological activities. The amino derivatives of these compounds especially are shown to have antitumor 1 and antiviral 2 activities, antimycobacterial [3][4][5][6][7] , anticancer 8,9 , diuretics [10][11][12] , anticonvulsant 13,14 , antitumor 15,16 , antiallergic agents 17 , antiphlogistic 18 , CNS depressant 19 , antitussive 20 , coronary vasodilator 21 , antihypertensive 22 , antiarrythmic agent 23 , immunosuppressing agent 24 , antispasmodic 25 ,cardiovascular 26 , antiepileptic 27 , anxiolytic agent 28 activities. Stimulated by the successful application of pyrazolopyrimidines, we herein report synthesis and docking studies of N-(2-Fluoro-5-(trifluoromethoxy)benzyl)-2-methylpyrido [2,3-d]pyrimidin-4-amine.…”