ChemInform Abstract: Synthesis and Characterization of N‐Substituted (S)‐1,2,3,4‐Tetrahydroisoquinoline‐3‐carboxamides and Thioamides as Organocatalysts for Asymmetric Aldol Reaction.

Abstract

Synthesis and Characterization of N-Substituted (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxamides and Thioamides as Organocatalysts for Asymmetric AldolReaction. -Title compounds (I) are synthesized and tested as catalysts for aldol reaction of nitrobenzaldehyde (II) with acetone. Reaction mechanism is studied. -(DRABINA*, P.; ANDROVIC, L.; PANOV, I.; HARMAND, L.; PADELKOVA, Z.; SEDLAK, M.; Heterocycles 89 (2014) 8, 1844-1859, http://dx.doi.org/10.3987/COM-14-13029 ; Inst. Org. Chem. Technol., Univ. Pardubice, CZ-532 10 Pardubice, Czech Republic; Eng.) -R. Langenstrassen 03-021