ChemInform Abstract: Synthesis and Characterization and Antiinflammatory and Antibacterial Evaluation of 3‐Arylidene‐7‐methoxychroman‐4‐ones.

Abstract

. -The antiinflammatory activity of the title compounds, e.g. (III), is found to be less effective than that of the standard diclofenac and the antibacterial activities in general are characterized as moderate. -(SHANKAR, T.; GANDHIDASAN*, R.; VENKATARAMAN, S.; Indian J.

An Expeditious and Safe Synthesis of Some Exocyclic α,β-Unsaturated Ketones by Microwave-Assisted Condensation of Cyclic Ketones with Aromatic Aldehydes over Anhydrous Potassium Carbonate

“…Some of the exocyclic α,β-unsaturated ketones, namely, aurones and E-3-benzylidenechromanones, are natural compounds [1,[5][6][7]. It may be mentioned here that several classes of compounds belonging to this category show interesting biological properties, for example, α,α -(E,E)-bis(arylidene)-cycloalkanones show antiangiogenic [8,9], quinine reductase inducer [10], arginine methyltransferase inhibitor [11], cytotoxic [12,13], cholesterol-lowering [14], and antitubercular [15] activities, and E-3-benzylidenechromanones and related homoisoflavonoids show antioxidant, antiinflammatory, antifungal, antiviral, antiallergic, antihistaminic, antirhinovirus, antimutagenic, angioproductive, hypocholesterolemic, and cytotoxic activities [7,16]. Moreover, α,α -(E,E)-bis(arylidene)-cycloalkanones find application as fluorescent materials [17] and in the preparation of nonlinear optical materials and liquid-crystalline polymers [18].…”

“…There has been addition of a good number of other methods in the literature subsequently [7,9,. However, some of the methods available so far suffer from drawbacks like use of toxic or corrosive reagents, expensive catalysts, hazardous solvents, long reaction times, tedious isolation procedure, and so forth, due to which the current literature shows a growing trend for developing environmentally benign methodologies for synthesis of different exocyclic α,β-unsaturated ketones [7,18,23,[33][34][35]37]. Mention of few such recent methods for synthesis of chalcones [38][39][40][41][42][43], a group of structurally related acyclic compounds, may be done in this connection.…”