ChemInform Abstract: Synthesis and Calcium Channel Antagonist Activity of Dialkyl 1,4‐Dihydro‐2,6‐dimethyl‐4‐ [4‐(1‐methoxycarbonyl‐1,4‐dihydropyridiyl)]‐3,5‐pyridinedicarboxylates.

Abstract

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Synthesis, Evaluation of Pharmacological Activities and Quantitative Structure–Activity Relationship Studies of a Novel Group of bis(4‐Nitroaryl‐1,4‐dihyropyridine)

“…Some studies suggested that heterocyclic substituent like nitro‐immidazolyl as bioisosteric replacement of nitrophenyl group at C‐4 gave active compounds with potent calcium antagonist activity (17–24).…”