ChemInform Abstract: Synthesis and Biological Activity of Substituted 5‐Hydroxy‐6‐bromoindoles.

Abstract

ChemInform Abstract The bromomethylindoles (I) react with thiophenol (II) to give the thioethers (III) which are coupled with the formaldehyde N,N-acetal, producing the dimethylaminomethyl derivatives (V). These are transformed into the hydrochlorides some of which have antiviral and antiarrhythmic activity.

Chikungunya Virus: Emerging Targets and New Opportunities for Medicinal Chemistry

“…The antiviral drug arbidol (12, Figure 20) was originally developed 20 years ago at the Russian Research Chemical and Pharmaceutical Institute. 120 Since 1990, it has been used in Russia for acute respiratory infections including influenza. So far, arbidol shows a wide range of activity against many RNA, DNA, enveloped and non-enveloped viruses.…”

“…The antiviral drug arbidol ( 12 , Figure ) was originally developed 20 years ago at the Russian Research Chemical and Pharmaceutical Institute . Since 1990, it has been used in Russia for acute respiratory infections including influenza.…”

Methods for the Synthesis of Isogramines and Their Chemical Properties. (Review)

“…Of course, the only possibility for 1,2,3,6-tetrasubstituted [46][47][48][49][50][51][52] and 1,2,3,6,7-pentasubstituted [18] 5-hydroxyindoles is dimethylaminomethylation at position 4. This method was used for the synthesis of arbidol, labelled with C 14 at position 2 and at the ethoxycarbonyl group, in order to study its pharmacokinetics [53].…”