ChemInform Abstract: Synthesis and Biological Evaluation of Some Novel 1‐Indanone Thiazolylhydrazone Derivatives as anti‐Trypanosoma cruzi Agents.

Abstract

Synthesis and Biological Evaluation of Some Novel 1-Indanone Thiazolylhydrazone Derivatives as anti-Trypanosoma cruzi Agents. -Most of the newly synthesized title compounds (III) show promising activity against epimastigotes, tryptomastigotes and amastigote forms. Among the tested derivatives, compound (IIId) exhibits the highest activity. -(CAPUTTO, M. E.; CICCARELLI, A.; FRANK, F.; MOGLIONI, A. G.; MOLTRASIO, G. Y.; VEGA, D.; LOMBARDO, E.; FINKIELSZTEIN*, L. M.; Eur. J. Med. Chem. 55 (2012) 155-163, http://dx.doi.org/10.1016/j.ejmech.2012.07.013 ; Dep. Farmacol., Univ. Buenos Aires, 1113 Buenos Aires, Argent.; Eng.) -G. Mueller 04-082