ChemInform Abstract: Synthesis and Biological Evaluation of Some Novel Isoxazoles and Cyanopyridines, a New Class of Potential Antitubercular Agents.

Doshi, Rajeev; Kagthara, Preeti; Parekh, H.

doi:10.1002/chin.199942042

Cited by 3 publications

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“…However, they are mostly known for their anticancer [ 7 ] and antimicrobial [ 8 ] activities. Also, pyridine derivatives, including those bearing various heterocyclic nuclei, have shown potent pharmacological properties, including antifungal [ 9 , 10 ], antitubercular [ 11 ], antimalarial [ 12 ], antibacterial [ 13 ], antimicrobial [ 14 ], or insecticide [ 15 ]. We report here the synthesis of new 1,3,4-thiadiazoles, 5-arylazothiazoles, and pyridines containing 1,2,3-triazole moiety.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

2017

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In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with hydrazonoyl halides. Also, hydrazonoyl halides were reacted with thiosemicarbazone and pyrazolylthioamide to give 1,3-thiazoles derivatives. Subsequently, 3-phenyl-2-en-1-one was used to synthesize substituted pyridines and substituted nicotinic acid ester. The latter was converted to its azide compound which was reacted with aromatic amines and phenol to give substituted urea and phenylcarbamate containing 1,2,3-triazole moiety. The newly synthesized compounds were established by elemental analysis, spectral data and alternative synthesis whenever possible.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

2017

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“…Pyridine and its derivatives have immense importance in the synthesis of various pharmacologically and biologically active compounds. Its complexes are reported to possess many pharmacological properties like antimicrobial [1], antifungal [2], [3] and antitubercular [4]. Its derivatives can also be used as nonlinear materials and photo chemicals [5].…”

Section: Introductionmentioning

confidence: 99%

4-PİRİDİNETİYONAMİD İLE Zn(II) KOMPLEKSİNİN SPEKTROSKOPİK ÖZELLİKLERİNİN DENEYSEL VE TEORİK OLARAK İNCELENMESİ

Vural¹

2016

SAUFenBilDer

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A novel compound of zinc (II) ion, [ZnCl2(peta)2] [peta: 4-Pyridinethioamide] was synthesized and characterized by XRD and FT-IR spectroscopy. The geometry around the Zn (II) center can be described as distorted tetrahedron. The crystal packing was stabilized by N-H•••Cl, N-H•••S and C-H•••S intermolecular hydrogen bonds. Molecular modeling of the Zn(II) complex was done by using the Hartree-Fock (HF) and Density Functional Theory (DFT) with 6-311++G (d, p) basis set. The calculated vibrational frequencies were compared with the corresponding experimental data. The time dependent DFT (TD-DFT) method by applying the integral equation formalism-polarized continuum model (IEF-PCM) was performed to investigate the electronic transitions in water and DMSO solvent.

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“…Also, pyridine derivatives of different heterocyclic nucleus have shown potent pharmacological properties like antifungal [32,33], antitubercular [34], antibacterial [35], antimicrobial [36], insecticida [37]. In view of these findings and in continuation to our previous work [38][39][40][41][42][43], we report here the convenient synthesis of Some New thieno [2,3-b]pyridines, pyrimidino [4',5':4,5]thieno [2,3-b]pyridines and pyridines incorporating 5-bromobenzofuran-2-yl moiety.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety

2015

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2-Sulfanyl-6-(2-thienyl)pyridine-3-carbonitrile, 1-Amino-6-(5-bromo-benzofuran-2-yl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile, thieno [2,3-b]pyridins, pyrimidino[4',5':4,5] thieno [2,3-b]pyridine, quinazoline and carbamate derivatives were synthesized from sodium 3-(5-bromobenzofuran-2-yl)-3-oxoprop-1-en-1-olate with. The newly synthesized compounds were elucidated by elemental analysis, spectral data, and alternative synthesis whenever possible and chemical transportation.

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ChemInform Abstract: Synthesis and Biological Evaluation of Some Novel Isoxazoles and Cyanopyridines, a New Class of Potential Antitubercular Agents.

Cited by 3 publications

References 0 publications

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

4-PİRİDİNETİYONAMİD İLE Zn(II) KOMPLEKSİNİN SPEKTROSKOPİK ÖZELLİKLERİNİN DENEYSEL VE TEORİK OLARAK İNCELENMESİ

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety

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