ChemInform Abstract: Synthesis and Biological Evaluation of 2‐Mercapto‐1,3‐benzothiazole Derivatives with Potential Antimicrobial Activity.

Structural and spectroscopic studies of two 1,3-benzothiazole tautomers with potential antimicrobial activity in different media. Prediction of their reactivities

“…In this way, these different results for thione and thiol probably support the study performed by Yildiz-Oren et al [48] and Franchini et al [7] related with the positions 2 and 6 in these derivatives which are crucial for antibacterial activity against Grampositive and Gram-negative bacteria Straits.…”

“…Recently, Franchini et al [7] have evaluated the potential antimicrobial activity that presents a series of 2-mercapto-1,3-benzothiazole derivatives where the 6-nitro-1,3-benzothiazole-2-thiol derivative shows an interesting antibacterial activity against Escherichia coli. Moreover, Yildiz-Oren et al [48] reported that positions 2 and 6 are crucial for antibacterial activity against Grampositive and Gram-negative bacteria Straits.…”

“…Benzothiazole derivatives present a wide range of biological activities such as, antitumor, antimicrobial, antitubercular, antimalaria, anticonvulsant, anthelmintic, antiinflammatory and analgesic among others, for which, they are of great pharmacological and medicinal interest [1][2][3][4][5][6][7][8]. The incorporation of different groups in the thiazol ring or in both rings improves their pharmacological properties, as reported for the 2-amino-5-(trifluoromethoxy)benzothiazole derivative, named riluzol, which has a NH 2 group in the thiazole ring and a O-CF 3 group in the benzene ring.…”