ChemInform Abstract: Synthesis and Antiviral Activities of N‐Mono‐ and/or N,N′‐Dicarbamoyl and Acyl Derivatives of Symmetrical Diamines.

Abstract

Cyclohexane derivatives Q 0040Synthesis and Antiviral Activities of N-Mono-and/or N,N'-Dicarbamoyl and Acyl Derivatives of Symmetrical Diamines. -The title compounds are obtained from symmetrical diamines (I), (IV), and (VIII) either by addition to iso(thio)cyanates (II) and (V), cleavage reaction of acid anhydride (IX), or N-acylation by acyl chloride. Reaction of diamine (VIII) with anhydride (IX) affords the N-monoacyl derivative (X), instead of undergoing cyclization as often observed in reactions of 1,2-diamines with acid anhydride. Compounds (III) and (VI) show significant antiviral activity against herpes simplex virus type 1. -(MIBU, N.; YOKOMIZO, K.; OISHI, M.; MIYATA, T.; SUMOTO*, K.; Chem.