ChemInform Abstract: Synthesis and Antitumor Activity of Pt(II) Complexes of Benzyl‐1,2‐diaminoethane Ligands.

Brunner, Henri; Hankofer, Peter; Treittinger, B.

doi:10.1002/chin.199031262

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“…Developed Schiff bases by condensing primary amines and carbonyl compounds [48]. A ketone (or aldehyde) that mimics Schiff base, commonly known as imine or azomethine, has the imine or azomethine group replaced for the carbonyl group (C=O) [49][50][51][52]. A molecule with an aryl or alkyl group (R) and a nitrogen atom connected, but not to hydrogen, is referred to as a Schiff base or a Schiff's base.…”

Section: The Creation Of Schiff Bases and Their Synthesismentioning

confidence: 99%

Review of the biological effects of Schiff bases and their derivatives, including their synthesis

Al-Mosawy

2023

Med.Sci.Jour.Adv.Res

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Aldehyde and amine buildup can shape Schiff's base complex of metal. Amino and carbonyl mixtures address a sizable group of ligands used to make Schiff bases that can facilitate with metal particles by the nitrogen iota of an azomethine particle. There has been much interest in these ligands. The C=N connect, in which different azomethines have been researched and professed to overwhelm massive organic activity, like impacts against microorganisms, growths, and infections, as well as against jungle fever and disease, might be the reason for the significance of azomethine replacements. Schiff base metal complexes have recently proven valuable compounds in various fields, including industry and medicine. Schiff's bases are the ideal substance with unmatched organic and inorganic chemistry service. because of the extensive range of biological movements that Schiff base ligand display and their complexes collection, use in clinical applications is observed to have affected the chemistry of Schiff bases, their derivatives, synthesis methods, and the specific biological applications for these compounds, along with the ones for antibacterial, antifungal, anticancer, and antiviral objectives, are defined on this overview. The manufacture, characterization, and biological results of Schiff bases and their derivatives can be discussed in this assessment.

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Section: The Creation Of Schiff Bases and Their Synthesismentioning

confidence: 99%

Review of the biological effects of Schiff bases and their derivatives, including their synthesis

Al-Mosawy

2023

Med.Sci.Jour.Adv.Res

View full text Add to dashboard Cite

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ChemInform Abstract: Synthesis and Antitumor Activity of Pt(II) Complexes of Benzyl‐1,2‐diaminoethane Ligands.

Abstract: Benzyl‐substituted dichloro(1,2‐diaminoethane)platinum(II) and its derivatives substituted at the phenyl ring of the benzyl group have a high antitumor activity accompanied by a low toxicity compared to cis‐PtCl2(NH3)2 ("cis‐Pt").

Cited by 1 publication

References 1 publication

Review of the biological effects of Schiff bases and their derivatives, including their synthesis

Review of the biological effects of Schiff bases and their derivatives, including their synthesis

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