Abstract:Synthesis and Antitumor Activity of Water-Soluble 2-Benzyl-1,2diaminobutane-α-oxycarboxylatoplatinum(II) Complexes.-The dichloroplatinum(II) complex of the title diamine shows antitumor activity accompanied by low toxicity compared to cis-platinum. However, the solubility in water has to be increased. Therefore, the chloride leaving groups are replaced by the anions of four α-hydroxycarboxylic acids. In each cage the geometrical trans/cis isomers (I) and (II) are obtained, which can be separated in the case of… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.