ChemInform Abstract: Synthesis and Antitumor Activity of Novel 2′,3′‐Diethanethio‐2′,3′,5′‐trideoxy‐5′‐triazolonucleoside Analogues.

Abstract

Synthesis and Antitumor Activity of Novel 2',3'-Diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside Analogues. -A series of novel triazoloribonucleosides (VII) is synthesized by the route described for the preparation of derivative (VI) and evaluated for antitumor activity. Substances with aryl substituted triazoles, e.g. (VIId) and (VIIe), show significantly improved activity towards a broad range of tumor cells whereas those without aryl substituents are inactive. -(YU, J.-L.; WU*, Q.-P.; ZHANG, Q.-S.; XI, X.-D.; LIU, N.-N.; LI, Y.-Z.; LIU, Y.-H.; YIN, H.-Q.; Eur.