ChemInform Abstract: Synthesis and Antitumor Activity of Vitamin B1 Derivatives Bearing a Ferrocene Fragment.

Abstract

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Synthesis, electrochemistry and anticancer activity of novel ferrocenyl phenols prepared via azide-alkyne 1,3-cycloaddition reaction

“…Since then many different types of anticancer-active ferrocenyl derivatives have been prepared (e.g. ferrocene conjugated with azoles [9,10], peptides [11], nucleobases [12], vitamins [13,14], DNA intercalators [15], enzyme inhibitors [16,17] or taxanes [18]). Many of these compounds exhibited significant cytotoxic [19e26]and antimalarial [27e30] and antibacterial [31] activities.…”