ChemInform Abstract: Synthesis and Antitumor Activity of Iso‐Piritrexim, a Lipophilic Folate Antagonist.

Abstract

Synthesis and Antitumor Activity of Iso-Piritrexim, a Lipophilic Folate Antagonist.-Two alternative strategies for the synthesis of iso-piritrexim (VII), which shows a moderate activity against some leukemia and lung cancer cell lines, are described. -(TROSCHUETZ, R.; ZINK, M.; DENNSTEDT, T.; Arch. Pharm. (Weinheim, Ger.) 328 (1995) 6, 535-540; Inst. Pharm. Lebensmittelchem., Univ.