ChemInform Abstract: Synthesis and Antioxidant Activity of Indolyl Chromenes.

Abstract

Synthesis and Antioxidant Activity of Indolyl Chromenes. -A simple and efficient method for the synthesis of indolyl chromenes (IV) by one-pot three-component reaction of various salicylaldehydes, malononitrile, and indole catalyzed by L-proline in water is developed. Most of these compounds show an excellent reducing power and free radical scavenging activity. -(SHANTHI, G.; PERUMAL*, P. T.; RAO, U.; SEHGAL, P. K.; Indian J. Chem

Preparation of 2-amino-5,7-dimethoxy-4-aryl/alkyl-4 H -chromene-3-carbonitriles using Na 2 O-Al 2 O 3 -P 2 O 5 glass–ceramic system

“…On the other hand, functionalized chromenes appear as an important structural component in both biologically active and natural compounds [1][2][3][4][5]. For example some of interesting molecules with chromene framework joined with different functional groups displaying rich medicinal chemistry and numerous applications such as anti-inflammatory, antioxidant, anti-HIV, antibacterial, and analgesic properties [6][7][8][9][10][11]. Amongst of them chromenes with cyano-functionality has potential applications in the treatment of rheumatoid, psoriasis and cancer [12].…”

Nano crystalline ZnO catalyzed one pot three-component synthesis of 7-alkyl-6H,7H- naphtho[1',2':5,6]pyrano[3,2-c] chromen-6-ones under solvent-free conditions

“…Chromenes are important class of heterocyclic compounds with a broad range of pronounced biological properties such as antioxidant [1,2], inhibitors of bacterial growth [3], anti-HRV serotype 1B within micro or submicromolar range with a high therapeutic index [4], cytotoxic [5], disrupt tumor vasculature and anticancer [6], antimicrobial [7], antihypertensive [8], and anti-tumor [9] activities. Also some of them have displayed a remarkable assay in the treatment of important diseases including Alzheimer's [10], high blood pressure [11], and as inhibitors of HIV virus [12].…”

Enantioselective Organocatalyzed Synthesis of 2-Amino-3-cyano-4H-chromene Derivatives

“…Among the different types of chromenes, we want to focus on 2-amino-3-cyano-4H-chromene scaffolds. They have received increasing attention in the last years due to the interesting biological activities that this specific family of heterocycles exhibits, such as antimicrobial [6][7][8] and antioxidant [9] activities as well as pro-apoptotic activity [10][11][12][13][14][15], conferring potential use as promising anticancer therapeutic drugs among others applications ( Figure 1). …”