ChemInform Abstract: Synthesis and Antimicrobial Activity of Some 2‐Pyridone Nucleosides Containing a Sulfonamide Moiety.

Moustafa, A. H.; El‐Sayed, Hassan A.; Haikal, Abd El‐Fattah Z.

doi:10.1002/chin.201341205

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“…Such AMPs kill microorganisms on contact and act as surfactants . The therapeutic and pharmacological properties of pyridone heterocycles make them candidates of contemporary choice for use in diverse applications such as antimicrobial, anticancer or antitumoral, antiviral, anti‐inflammatory, etc. Antimicrobial potential of 2‐pyridone heterocyclic compounds has been extensively studied and documented .…”

Section: Introductionmentioning

confidence: 99%

“…In view of the above considerations, a new bio‐inspired polymer having a 2‐pyridone structure was synthesized, namely poly(4‐vinyl‐2‐pyridone) (p‐VPn). It has a cyclic amide structure similar to the ones mentioned above . p‐VPn was further functionalized to its N ‐alkylated cationic derivative, poly( N ‐hydroxyethyl)‐4‐vinyl‐2‐pyridonium chloride (p‐HEVPnCl), to obtain a choline analogous polymeric structure with pendant —CH 2 CH 2 OH groups.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial properties of bio-inspired poly(4-vinyl-2-pyridone) and itsN-alkylated cationic derivatives

2016

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Developing new antimicrobial polymers and designing new antimicrobial materials are important research areas for overcoming bacterial resistance. In the present study a new polymer, poly(4-vinyl-2-pyridone), having bioactive structure analogous to that of naturally occurring heterocyclic compounds, was synthesized from 4-vinylpyridine following a simple protocol. To augment the antibacterial properties of the synthesized polymer, N-alkylation of the heterocyclic pyridone moieties was achieved with ethylene chlorohydrin (2-chloroethanol) to generate choline analogous structure. Also, its N-butylated analogue was synthesized as a reference compound to study structure-activity relationship. Structures of the polymers were confirmed using various characterization techniques. Antimicrobial efficacy of the polymers was determined using the minimum inhibitory concentration method in parallel experiments. The test microorganisms used were a Gram (+) bacterium (Staphylococcus epidermidis), Gram (−) bacteria (Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli) and a fungus (Candida albicans). Both the polymer derivatives are far more effective antimicrobial agents than the pristine polymer. Trends in the antimicrobial efficacy of these polymers correlate with their zeta potential values.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of bio-inspired poly(4-vinyl-2-pyridone) and itsN-alkylated cationic derivatives

2016

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ChemInform Abstract: Synthesis and Antimicrobial Activity of Some 2‐Pyridone Nucleosides Containing a Sulfonamide Moiety.

Abstract: Compounds (Va) and (VIb) possess significant antibacterial activity while all of the tested compounds show antifungal activity.

Cited by 1 publication

References 1 publication

Antimicrobial properties of bio-inspired poly(4-vinyl-2-pyridone) and itsN-alkylated cationic derivatives

Antimicrobial properties of bio-inspired poly(4-vinyl-2-pyridone) and itsN-alkylated cationic derivatives

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