ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Bis(2‐pyrazolin‐3‐yl)benzenes.

Abstract

ChemInform Abstract Condensation of 1,3-diacetylbenzene (I) with the benzaldehydes (II) produces the 1,3-cinnamoylbenzenes (III) which react with hydrazine hydrate (IV) to form the 3,3'-m-phenylenebis(5-aryl-2-pyrazolines) (V). The compounds (V) are converted to the derivatives (VI) which have no antibacterial activity but show significant antifungal activity. Cyclocondensation of the 1-aryl-2-propen-1-ones (IX), obtained from benzene-1,4-dicarboxaldehyde (VII) and the acetophenones (VIII), with hydrazine hydrate (IV) leads to the formation of the pyrazoline derivatives (XI).

Synthesis of 1,4-phenylene bridged bis-heterocyclic compounds

“…[6][7][8][9][10][11][12] Therefore, it is not surprising that research on the synthesis of polyfunctionalized heterocyclic compounds has received significant attention. In recent years, attention has been increasingly paid to the synthesis of bis-heterocyclic compounds which exhibit various biological activities, [13][14][15][16][17][18][19][20] including antibacterial, fungicidal, tuberculostatic, antiamoebic, and plant growth regulative properties. The current first specialized review covers the synthesis of 1,4-phenylene-bisheterocyclic compounds from the late 1972 until 2011, and our survey of the literature on the synthesis of these heterocyclic has been divided according to the number of heteroatom in the heterocyclic.…”