ChemInform Abstract: Synthesis and Antiinflammatory Activity of Three Nitro Chalcones.

Abstract

Synthesis and Antiinflammatory Activity of Three Nitro Chalcones. -The three new compounds (III) show antiinflammatory protective, time dependent effect by both oral and intraperitoneal administration. Compound (IIa) is found to be the most effective, one with no statistically significant difference when compared to reference drug (meloxicam). -(GOMEZ-RIVERA, A.; AGUILAR-MARISCAL, H.; ROMERO-CERONIO, N.; ROA-DE LA FUENTE, L. F.; LOBATO-GARCIA*, C. E.; Bioorg. Med. Chem. Lett. 23 (2013) 20, 5519-5522, http://dx.doi.org/10.1016/j.bmcl.2013.08.061 ; Div. Acad. Cienc. Basicas, 86690 Tabasco, Mex.; Eng.) -C. Cyrus

Anti-inflammatory activity and molecular docking studies of quinolyl-thienyl chalcone

“…Chalcones possesses a broad spectrum of pharmacological activities. They have been shown to possess antibacterial, anti-protozoal, anti-malarial (Hayat et al, 2011) and anti-inflammatory activities (Gómez-Rivera et al, 2013). The compound selected for current investigations was synthesized as reported earlier (Rizvi et al, 2012).…”