ChemInform Abstract: Synthesis and Antihyperlipidemic Activity of Some Novel Condensed 2‐Chloroalkyl‐4‐chloro/hydroxy‐5,6‐disubstituted Pyrimidines.

Kathiravan, M. K.; Shishoo, C. J.; Kumar, Krishnan Girish; Roy, Saroj K.; Mahadik, Kakasheb R.; Kadam, Shivajirao; Jain, Kishor S.

doi:10.1002/chin.200804174

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2011

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“…We have reported thieno(2,3-d)pyrimidine derivatives as antihyperlipidemic [17] Gefitinib analogues [18]. Very recently we have identified condensed thieno(2,3-d) pyrimidine derivatives as bioisosteres of rutaecarpine possessing antihypertensive activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Vyawahare¹,

Hadambar²,

Chothe³

et al. 2011

J Chem Biol

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Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

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Section: Introductionmentioning

confidence: 99%