ChemInform Abstract: Synthesis and Antibacterial Activity of 1,3‐Diaryl‐4‐cyanopyrazoles.

Abstract

Pyrazole derivatives R 0180Synthesis and Antibacterial Activity of 1,3-Diaryl-4-cyanopyrazoles. -Compounds (IVc) and (IVd) exhibit high antibacterial activity comparable to that of commercial antibiotics, linezolid and ciprofloxacin. -(PRAKASH*, O.; PUNDEER, R.; RANJAN, P.; PANNU, K.; DHINGRA, Y.; ANEJA, K. R.; Indian J.

Synthesis and Antimicrobial Activity of Novel Thiazole Substituted Pyrazole Derivatives

“…Pyrazole and thiazole rings are privileged scaffolds for the generation of target compounds for drug discovery. The structural diversity and biological importance of pyrazoles and thiazoles have made them attractive targets for synthesis. Pyrazole and thiazole rings present in the same molecule could be convenient models for investigation of their biological activity.…”

Some New Pyrazolyl Pyrazolones and Cyanopyrazolyl Acrylates: Design, Synthesis and Biological Evaluation

“…They are utile for dyes, pigments, pesticides, chelating and extracting agents, chromatography, petrochemicals, as laser materials and 1 H NMR shift reagents . Keeping in mind the high incidents of antimicrobial resistance, medicinal significance of pyrazolones and in continuation of our research programme on exploring the synthetic and antimicrobial potential of pyrazoles and their derivatives, we discuss herein the synthesis of some new 3‐amino‐4‐[(3‐aryl‐1‐phenyl‐1 H ‐pyrazol‐4‐yl)methylene]‐1 H ‐pyrazol‐5(4 H )‐ones (pyrazolylpyrazolones) ( 4 ) and ethyl 2‐cyano‐3‐(3‐aryl‐1‐phenyl‐1 H ‐pyrazol‐4‐yl) acrylates ( 3 ) with the objective to evaluate their antibacterial and antifungal potential.…”

Synthesis and antibacterial evaluation of some new 4‐substituted‐3‐aryl‐1‐(2,6‐dimethylpyrimidin‐4‐yl)pyrazoles

“…Furthermore, it has been reported in literature that placement of a cyano moiety on the azole often generates analogs with interesting antibacterial activities in vivo and in vitro , in particular 3‐cyano and 4‐cyano pyrazoles [17, 18]. Keeping this in view, 3‐aryl‐1‐(2,6‐dimethylpyrimidin‐4‐yl)pyrazole‐4‐carboxaldehydes ( 2 ) were transformed to 3‐aryl‐1‐(2,6‐dimethylpyrimidin‐4‐yl)‐4‐cyanopyrazoles ( 4a , 4b , 4c , 4d , 4e , 4f , 4g ) in good yields by making use of inexpensive and commercially available reagent, acetic anhydride (Scheme ).…”