ChemInform Abstract: Synthesis and Aggregation Behavior of Chiral Cysteine Amphiphiles with s‐Triazine as Connecting Unit.

Abstract

ChemInform Abstract Various homologous liposome building blocks of type (IV) with L-cysteine as chiral hydrophilic head group are synthesized starting from the known chelate (I) via the preamphiphiles (III). s-Triazine serves as connecting unit between cysteine and the lipophilic alkyl chains. The phase transition temp. of the lipids are determined by DSC or fluorescence anisotropy. It can be shown that the relationship between nature and length of the chains and the phase transition temp. corresponds to that of phospholipids. Encapsulation experiments with ionic water-soluble dyes give some hints that the vesicles prepared in phosphate buffer (pH 7.0) interact with cationic but not with anionic hydrophilic substances.