ChemInform Abstract: Synthesis, Analgesic and Antiinflammatory Evaluation of Some New 3H‐Quinazolin‐4‐one Derivatives.

Abstract

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Utility of 2-Methyl-quinazolin-4(3H)-one in the Synthesis of Heterocyclic Compounds with Anticancer Activity

“…Moreover, the presence of 2-amino benzoic acid moiety on the C 4 -quinazoline ring as in compound 29 exhibited remarkable increase in activity towards HepG2 cell line showing IC 50 19.95 µM/L.…”

Prediction of ADME/Tox properties, 2D,3D QSAR and molecular docking approach of 2,3‐disubstituted‐Quinazolin‐4(3H)‐ones using X‐ray crystal structure of Staphylococcus aureus (1T2W) Sortase A

“…have been in the market or are currently in clinical trials for various cancer treatments. Various chemical entities of quinazolines reported to have pharmacological effects includes antitubercular, [ 12,13 ] antibacterial, [ 14 ] antimicrobial, [ 15 ] anti‐inflammatory, [ 16 ] Antitumor [ 17 ] and CNS depressant [ 16 ] antifungal, [ 18,19 ] antimalarial, [ 20 ] antihypertensive, [ 21 ] diuretic, [ 22,23 ] inhibition of derived growth factor receptor phosphorylation, [ 24 ] antagonism of ghrelin receptor, [ 25 ] anticonvulsant, [ 26 ] COX‐2 inhibitory activities, analgesic and anti‐inflammatory. [ 27,28 ] It has been claimed that substituting different functional groups, atoms, or heterocyclic rings at the C‐2 or C‐3 location of the quinazolinone nucleus can increase the biological activity.…”