ChemInform Abstract: Syntheses of Quinazolinones from 2‐Iodobenzamides and Enaminones via Copper‐Catalyzed Domino Reactions.

Abstract

Syntheses of Quinazolinones from 2-Iodobenzamides and Enaminones viaCopper-Catalyzed Domino Reactions. -The double bond geometry of the enaminones plays a crucial role since E-enaminones show a significantly enhanced reactivity upon addition of an external ligand whereas Z-enaminones do not require the latter. The steric hindrance of the enaminone and the nucleophilicity of the amide nitrogen strongly influences the reaction yields. -(SONGSICHAN, T.; PROMSUK, J.; RUKACHAISIRIKUL, V.; KAEOBAMRUNG*, J.; Org. Biomol. Chem. 12 (2014) 26, 4571-4575, http://dx.doi.org/10.1039/c4ob00400k ; Dep. Chem., Prince Songkla Univ., Hat Yai 90112, Thailand; Eng.) -F. Schill 49-172