ChemInform Abstract: Syntheses and Evaluation as Glycosidase Inhibitor of 1,5‐Dideoxy‐1,5‐imino‐D‐glucitol Analogues of Salacinol, a Potent α‐Glucosidase Inhibitor Isolated from Ayurvedic Medicine, Salacia reticulata.

Abstract

Carbohydrates U 0500Syntheses and Evaluation as Glycosidase Inhibitor of 1,5-Dideoxy-1,5-imino--D-glucitol Analogues of Salacinol, a Potent α-Glucosidase Inhibitor Isolated from Ayurvedic Medicine, Salacia reticulata. -The N-alkylated deoxynojirimycin (I) and its O-desulfate (II) are found to possess almost equal inhibitory activity against rat intestinal maltase and sucrase like salacinol. -(TANABE, G.; HATANAKA, T.; MINEMATSU, T.; MATSUDA, H.; YOSHIKAWA, M.; MURAOKA*, O.; Heterocycles 79 (2009) 1, 1093-1100; Sch. Pharm. Sci., Kinki Univ., Higashi-Osaka 577, Japan; Eng.) -H. Toeppel 41-195