ChemInform Abstract: Suzuki Cross‐Coupling of meso‐Dibromoporphyrins for the Synthesis of Functionalized A₂B₂ Porphyrins.

Abstract

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Synthesis and Functionalization of Porphyrins through Organometallic Methodologies

“…The group of de Lera reported the synthesis of A 2 B 2 -type porphyrins through Suzuki−Miyaura cross-coupling between meso-bromoporphyrin 49.1 and arylboronic acids (Scheme 49). 192 They developed milder reaction conditions for coupling by using catalytic amount of Pd(PPh 3 ) 4 and aqueous Na 2 CO 3 as a base in DMF, which ensured good coupling rates for porphyrins functionalized with electrophilic groups. Under these conditions, an excess of boronic acid is required to obtain isolable products due to adventitious hydrolytic protiodeborylation.…”