ChemInform Abstract: STUDIES ON SOME THIOSEMICARBAZONES AND 1,3,4‐THIADIAZOLINES AS POTENTIAL ANTITUBERCULAR AND ANTIBACTERIAL AGENTS

Abstract

Aus dem Thiosemicarbazid (I) werden mit aromatischen Aldehyden (II) die Thiosernicarbazone (III) hergestellt, die nach Isolierung zu den Thiadiazolinen (IV) cyclisiert werden und auf antibaktenelle Wirkung geprüft werden.

Novel synthesis of palladium (II) complexes derived from 3-arylsydnone-4-carbaldehyde N(4)-phenylthiosemicarbazones and biological activity

“…Thiosemicarbazones (TSCs) reportedly have potential therapeutic activity and are widely applied in medicine especially in the treatment of tuberculosis . Various compounds with a TSC moiety also exhibit biological activity .…”

Synthesis and antimicrobial activity of novel (3,5-dichloro-4-((5-aryl-1,3,4-thiadiazol-2-yl)methoxy) phenyl) aryl methanones

“…During recent years, intense investigations and tremendous efforts have been deployed to find a suitable candidate which will combat the resistance developed within the microorganisms. Heterocyclic compounds containing five-membered ring, in particular 1,3,4-thiadiazole gained importance because of their versatile biological properties such as antimicrobial, (Desai et al, 1992;Gawande et al, 1987;Mamolo et al, 1996) antituberculosis, (Shucla et al, 1984) anti-inflammatory, (Mullican et al, 1993;Song et al, 1999;Labanauskas et al, 2001) anticonvulsant, (Chapleo et al, 1988) antihypertensive, (Turner et al, 1988) local anaesthetic, (Mazzone et al, 1993) anticancer (Miyamoto et al, 1985;Chou et al, 2003) and hypoglycemic activities. (Hanna et al, 1995) Benzophenone is a prototypical aromatic carbonyl compound that has been extensively studied.…”

Molecular Modeling study of Protein Kinase PKnB from Mycobacterium Tuberculosis with derivatives of 1, 3, 4- Thiadiazoles

“…Aberrant kinase activity is implicated in numerous human diseases and, not surprisingly, protein kinases represent today one of the most important groups of drug targets [9] and [10] . Here we report that thiadiazole, a compound reported as anti-microbial [10][11][12][13] and anti-tubercular agent [14][15][16][17][18] is a PKnB inhibitor capable of preventing mycobacterial cell growth, suggesting that bacterial kinases may also represent a potential target for drug design and derivatives of Thiazdiazoles exhibit a property of inhibiting mycobacterial growth. [1] ) using the program AutoDock4 [19] .…”