ChemInform Abstract: Studies on Bi‐Heterocyclic Compounds. Part 2. 5‐Substituted Thiazolones.

Yamazaki, Hiroshi; Harada, Hiroshi; Matsuzaki, K.; Yoshioka, Kōta; Takase, Mai; Ohki, Eiji

doi:10.1002/chin.199031192

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“…Other study display the reaction of (3-phenylpyridin-2-yl)methylamine with dichloroacetaldehyde to form the compound methyl 3-methyl-8-phenylimidazo[1,5-a]pyridine-1-carboxylate; it is noteworthy that this compound produce positive inotropic activity in a papillary cat muscle model 7 . Besides, a 5-(3-chloropyridin-4-yl)-4-methyl-1,3-thiazolidin-2-one was synthesized from a ketone derivative and pyridinium salt with positive inotropic activity on guinea pig left atria 8 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

et al. 2022

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Background There are studies, which suggest that some diazocine derivatives can exert effects on the cardiovascular system; however, these effects are not very clear. Objective The aim of this research was to evaluate the biological activity of a diazocine derivative against heart failure translated as area infarct. Methods Biological activity produced by diazocine derivatives against heart failure was determinate using an ischemia/reperfusion injury model. Besides, to characterize the molecular mechanism of effect exerted by diazocine derivative on left ventricular pressure (LVP) was determinate in an isolated rat heart model using nifedipine, PINAME TXA2, and quinalizarin as controls. Results The results showed that diazocine derivative decrease the infarct area and increase the LVP. However, the effect produced by diazocine derivative on LVP was inhibited in the presence of quinalizarin. Conclusions The results indicate that biological activity produced by diazocine derivative on left ventricular pressure is through protein CK2 activation; this phenomenon could be translated as a decrease in both infarct area and heart failure.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

et al. 2022

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ChemInform Abstract: Studies on Bi‐Heterocyclic Compounds. Part 2. 5‐Substituted Thiazolones.

Abstract: The pyridinium, pyrazidinium, or quinolinium salts (I) are coupled with the thiazolone (II) to give the dihydroazaarylthiazolones (III) which are oxidized with sulfur to produce the azaarylthiazolones (IV).

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Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

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