ChemInform Abstract: STRUCTURE AND ANTIMICROBIAL ACTIVITY OF 2‐HYDROXYCINNAMIC ALDEHYDE DERIVATIVES

Antioxidative Activities of Natural Hydroxy-Bearing Cinnamaldehydes and Cinnamic Acids: A Comparative Study

“…Cinnamaldehydes are more fatsoluble than their corresponding acids, so it is easier for cinnamaldehydes to adhere to the lipid part of erythrocytes than their corresponding acids, and thus cinnamaldehydes showed stronger hemolysis inhibitory activities than their corresponding acids. Certain phenolic compounds may incorporate into the hydrophobic core of the membrane bilayer, causing a reduction in membrane fluidity [17][18][19] [9,11,12,14], such as antimicrobial, anti-inflammatory, and as a good candidate for cancer therapy. Another possible cause for the higher activities of aldehydes is that the carbonyl group of cinnamaldehydes can easily combine with the residual amino group of the protein of RBCs forming reversible imine structure [20].…”

“…Some hydroxybearing cinnamaldehydes, such as ocoumaraldehyde from bark of cinnamon，p-coumaraldehyde， ferulaldehyde，and caffeic aldehyde have been widely studied and found to be good bioactive compounds. Much attention has been paid to their antioxidative activities [8][9][10][11][12][13][14]. But the comparative studies on the antioxidative effects of the hydroxy-bearing cinnamaldehydes with their corresponding acids are few.…”