volume 30, issue 44, Pno-no 2010
DOI: 10.1002/chin.199944083
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Philippe Dorizon,
Guifa Su,
Gitte Ludvig
et al.

Abstract: StereoselectiveSynthesis of Highly Functionalized Cyclopropanes.Application to the Asymmetric Synthesis of (1S,2S)-2,3-Methanoamino Acids.-Palladium-catalyzed alkylation-cyclization of dichlorobutene (I) with various substituted acetonitriles (II) in the presence of base proceeds with high diastereoselectivity (88-100% d.e.) to furnish trans-functionalized cyclopropanenitriles (III) in good yields. In contrast, various approaches to realize the asymmetric version of this one-pot alkylationcyclization sequence…

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