ChemInform Abstract: Spiruchostatins A and B, Novel Gene Expression‐Enhancing Substances Produced by Pseudomonas sp.

Masuoka, Yuhta; Nagai, Atsuko; Shin‐ya, Kazuo; Furihata, Kazuo; Nagai, Koji; Suzuki, Kenichi; Hayakawa, Yoichi; Seto, Haruo

doi:10.1002/chin.200112193

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Hiv Latency and Plausible Therapeutic Strategies Toward Hiv ...1

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2021

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“…Moreover, this compound is more efficacious in multiple cell models compared to vorinostat [40] . Accordingly, a series of romidepsin derivatives have been isolated and characterized, including thailandepsins, spiruchostatins, chromopeptide A, and romipeptides (Figure 4) [41][42][43][44] . Recently, a clinical trial demonstrated that significant viral reactivation can be safely induced using romidepsin in HIVsuppressed individuals undergoing long-term ART.…”

Section: Hiv Latency and Plausible Therapeutic Strategies Toward Hiv ...mentioning

confidence: 99%

Natural products against HIV latency

Otsuki

Zhang

Wei

2021

Acupuncture and Herbal Medicine

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Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus (HIV) replication and transforming HIV infection from a fatal disease to a manageable chronic disease. However, the latent HIV reservoir persists in the body of HIV-infected individuals and is prone to reactivation. Therefore, the development of new treatment methods aimed at a complete cure for HIV is needed. The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as “shock and kill.” This strategy involves the use of latency-reversing agents (LRAs) to activate the HIV provirus in latent viral reservoir cells. Many LRAs can be obtained from natural resources, including plants and marine organisms. In this review, we provide an overview of natural products used to eliminate HIV latency.

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