ChemInform Abstract: Spirocyclic Dihydropyridines by Electrophile‐Induced Dearomatizing Cyclization of N‐Alkenyl Pyridinecarboxamides.

Abstract

N-alkenyl pyridinecarboxamides undergo dearomatizing spirocyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation. The products are spirocyclic dihydropyridines which are readily convertible into drug-like scaffolds. -(SENCZYSZYN, J.; BRICE, H.; CLAYDEN*, J.; Org. Lett. 15 (2013) 8, 1922-1925, http://dx.doi.org/10.1021/ol400571j ; Sch. Chem., Univ. Manchester, Manchester M13 9PL, UK; Eng.) -Bartels 35-091