ChemInform Abstract: SOME NEW 2‐ARYL‐3‐ISONICOTINAMIDO‐4‐THIAZOLIDINONES AND THEIR 5‐CARBOXYMETHYL HOMOLOGS AS POTENTIAL ANTITUBERCULAR AND ANTIBACTERIAL AGENTS

Desai, N. C.; Shukla, H. K.; Thaker, K. A.

doi:10.1002/chin.198504201

Cited by 4 publications

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“…Thiosemicarbazones can be used for making complex formation of metallic ions[4–13]. Thiosemicarbazones exhibit various biological activities such as antituberculosis[1415], antimicrobial[916–18], antiinflammatory[19], anticonvulsant[920], antihypertensive[21], local anesthetic[22], anticancer[1023], hypoglycemic[24], and cytotoxic activities[9], also antioxidant agents[1125]. A number of galactosyl thiosemicarbazide derivatives showed significant in vivo antimicrobial and in vitro antioxidant activity, which could be used as leads for the development of effective antiatherosclerotic agents[2202627].…”

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confidence: 99%

Synthesis, structure and antioxidant activity of (tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of substituted benzaldehydes

Thành¹,

Hoai²

2012

Indian J Pharm Sci

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Some new substituted benzaldehyde (2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl) thiosemicarbazones were synthesised by reaction of 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl thiosemicarbazide and different substituted benzaldehydes. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, 1 H NMR, 13 C NMR and MS) method. The antioxidant activity of these thiosemicarbazones was evaluated, in vitro and in vivo, and it's shown that some of these compounds had significant antioxidant activity.

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confidence: 99%

Synthesis, structure and antioxidant activity of (tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of substituted benzaldehydes

Thành¹,

Hoai²

2012

Indian J Pharm Sci

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“…Metal complexes of Schiff bases occupy a central role in coordination chemistry for analytical, physical, and biochemical purposes (Desai and Thaker, 1990;Lamrani et al, 1995;Attari et al, 1997;Zhang et al, 1996;Li et al, 1997;Ibrahim et al, 1998;Levitin and Tsikalova, 1998;Pereira et al, 1998;Zhou et al, 1999;Anacona and Brito, 1999;Campos et al, 1999;Taha, 2001;Zhao and Yuan, 1993;Issa and Hegazy, 2001;Sengupta et al, 2006;El-Tabl et al, 2007Gao-fei et al, 2007;Singh and Katiyar, 2008;Hegazy and Al-Motawaa, 2011;Hegazy, 2001). Coordination complexes with substituted salicylaldehydes have shown diverse structures and properties generating a variety of stereochemistries and a wide range of bonding interactions (Yoshida and Yamada, 1967;Elmali et al, 2000;Soliman and Linert, 1999;Zolezzi et al 1999).…”

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confidence: 99%

Synthesis, Characterization and Antibacterial Activities of New Pd(II) And Pt(IV) Complexes of Some Unsymmetrical Tetradentate Schiff Bases

Hegazy

2012

ACSJ

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New palladium (II) and platinum (IV) complexes with a series of unsymmetrical tetradentate Schiff bases derived from aromatic 2-hydroxy aldehydes in an ethanolic medium were synthesized and characterized by elemental analyses, melting points, magnetic susceptibility, thermogravimetry, differential scanning calorimetry (DSC), infrared (IR), and electronic spectral measurements. The purity of the ligands and the metal complexes are confirmed by microanalysis, while the unsymmetrical nature of the ligands was further corroborated by 1 H-NMR spectroscopy. Comparison of the IR spectra of the Schiff bases and their metal complexes confirm that the Schiff bases act as tetradentate and coordinated via the two azomethine nitrogens and the two phenolic oxygens. Magnetic moments and electronic spectral data confirm square planar geometry for the Pd(II) and Pt(IV) complexes. Thermal studies reveal a general decomposition pattern, whereby the complexes decomposed partially in a single step due to loss of part of the organic moiety. The Schiff

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“…The MICs of synthesized compounds were carried out by broth micro dilution method as described by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Anargyros et al, 1990;Shah et al, 1985;Desai et al, 1984. Antibacterial activity was screened against two gram positive bacteria (S. aureus ATCC 6538P, and Streptococcus pyogenes ATCC 8668) and two gram negative bacteria (E. coli ATCC 8739, and P. aeruginosa ATCC 9027).…”

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confidence: 99%

Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents

Vinay¹,

Marjadi²,

Yadav³

2017

Arabian Journal of Chemistry

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A novel series of Schiff bases 4a-n was prepared from 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl) ethyl)acetamide. Thiazolidinone 5a-n derivatives were prepared from the reaction of Schiff base and thioglycolic acid. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1 H NMR, 13 C NMR and Mass spectral data. All the compounds were screened against different strains of bacteria and fungi. These active compounds impelled us to study their antitubercular activity. Compounds 4b, 5a, 5b, 5d, 5e, 5f, 5k, 5l and 5n emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 5k showed better antitubercular activity compared to Rifampicin.ª 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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ChemInform Abstract: SOME NEW 2‐ARYL‐3‐ISONICOTINAMIDO‐4‐THIAZOLIDINONES AND THEIR 5‐CARBOXYMETHYL HOMOLOGS AS POTENTIAL ANTITUBERCULAR AND ANTIBACTERIAL AGENTS

Abstract: Die Benzaldehyde (I) kondensieren mit Isonicotinsäurehydrazid (II) zu den Aroylhydazonen (III), an die sich die α‐Mercaptocarbonsäuren (IV) unter Ringschluß zu den Thiazolidinonen (V) addieren.

Cited by 4 publications

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Synthesis, structure and antioxidant activity of (tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of substituted benzaldehydes

Synthesis, structure and antioxidant activity of (tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of substituted benzaldehydes

Synthesis, Characterization and Antibacterial Activities of New Pd(II) And Pt(IV) Complexes of Some Unsymmetrical Tetradentate Schiff Bases

Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents

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