ChemInform Abstract: Simplification of Antitumoral Phenanthroindolizidine Alkaloids: Short Synthesis of Cytotoxic Indolizidinone and Pyrrolidine Analogues.
Abstract:Simplification of Antitumoral Phenanthroindolizidine Alkaloids: Short Synthesis of Cytotoxic Indolizidinone and Pyrrolidine Analogues. -The synthesis of hydroxyl proline derived indolizidinone and pyrrolidine derivatives bearing aromatic substituents is described. The compounds show cytotoxic activity against human neuroblastoma SHSY-5Y and human breast cancer MCF-7. Best cytotoxic abilities are found for the compounds (VIb) and (VIIb), as well as (VIII) and (IX). -(MIGUELEZ, J.; BOTO*, A.; MARIN, R.; DIAZ, M.… Show more
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