ChemInform Abstract: Sesquiterpenoids from Scorzonera hispanica L.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro

“…Additionally, S. latifolia aerial part extract displayed notable activity. one-acetate (15), and olean-12-en-11-one-3-acetyl (16)] were also tested for their inhibitory effects on the TNF-α and IL-1β production.…”

“…From the above mentioned, we suggested that chlorogenic acid (8), derivatives of dicaffeoyl-quinic acid (6 and 7), and flavonoids, especially quercetin-3-O-β-D-glucoside (1) and hyperoside (2) could be responsible for the anti-inflammatory activity of tested extracts. Therefore, further experiments were carried out with phenolic compounds previously obtained from Scorzonera species (1)(2)(3)(4)(5)(6)(7)(8), to assay the inhibition of TNF-α and IL-1β production in THP-1 cells, and later also with triterpenes 9-16, because taraxasterol acetate (9) isolated from S. latifolia showed previously analgesic activity in vivo in writhing and tail-flick tests [21] and also other triterpenoid substances like lupeol derivatives (10 and 11), β-sitosterol (12) and other triterpenes (13)(14)(15)(16) could potentially demonstrate anti-phlogistic effect [38,39]. Unfortunately, only weak activity of compounds tested was observed, and no statistically significant activity has been observed in comparison with standard used (prednisone, Supplementary Materials, Figure S1).…”

“…Plants from the genus Scorzonera, belonging to Asteraceae family, are used as food as well as medicinal plants not only in Turkey, but also in some other European countries [12][13][14]. Different species of Scorzonera have been used in European traditional medicine against pulmonary diseases, colds, for the treatment of wounds as well as for their stomachic, diuretic, galactagogue, antipyretic, and appetizing effects [12,13,15]; in Mongolian traditional medicine for the treatment of diarrhea, lung edema, parasitic diseases, and fever caused by bacterial, and viral infections [13]; in Libyan folk medicine for the treatment of hepatic pains [16]; and in Chinese, as well as in Tibetan folk medicine against breast inflammation and abscess due to their antipyretic and anti-inflammatory activities [17]. Additionally, in Turkish folk medicine different species of this genus have been reported to be used in treatment of rheumatism, pain, wound healing, as well as arteriosclerosis, kidney diseases, hypertension, and diabetes [18,19].…”

“…HPLC analytical method previously published by [22] was optimized and composition of the extracts was tested qualitatively to select main compounds for activity testing. According to this and previous work, eight phenolics: quercetin-3-O-β-D-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-O-dicaffeoyl-quinic acid (7), and chlorogenic acid (8), which were isolated as the major phenolic compounds in current study, and terpenoids 9-16, which have been isolated previously [taraxasterol acetate (9), lupeol (10), lupeol acetate (11), β-sitosterol (12), 3-β-hydroxy-fern-8-en-7-one-acetate (13), urs-12-en-11-one-3-acetyl (14), 3-β-hydroxy-fern-7-en-6-one-acetate (15), and olean-12-en-11-one-3-acetyl (16)] were also tested for their inhibitory effects on the TNF-α and IL-1β production.…”

Micromorphology of the epidermis and anatomical structure of the leaves of Scorzonera hispanica L.

“…Biologically active substances contained in the tissues of S. hispanica, e.g., inulin [12,13], sesquiterpenoids including bisabolane [14][15][16], lignans including syringaresinol [16,17], polyphenols such as flavonoids and phenolic acids [16], may play a role in the prevention and treatment of various diseases.…”