ChemInform Abstract: Sesquiterpenoids from Atractylodes macrocephala Act as Farnesoid X Receptor and Progesterone Receptor Modulators.

Abstract

Sesquiterpenoids from Atractylodes macrocephala Act as Farnesoid X Receptor and Progesterone Receptor Modulators. -Atractylenolide II (Ia) and III (Ib) act both as farnesoid X receptor (FXR) antagonists and (Ib) also behaves as progesterone receptor (PR) agonist. -(TSAI, C.-J.; LIANG, J.-W.; LIN*, H.-R.; Bioorg. Med. Chem. Lett. 22 (2012) 6, 2326-2329, http://dx.