ChemInform Abstract: SERRS Detection of PNA and DNA Labeled with a Specifically Designed Benzotriazole Azo Dye.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Dye Labelling of Nucleosides

“…Labelled nucleotides and oligonucleotides have many significant biochemical and analytical uses. Traditionally 32 P, 15 N and 14 C have been used for nucleic acid labelling but because of their disadvantages (handling and disposing of hazardous material, long exposure times, short half‐lives and limited stability of probes (1–3)) a variety of non‐isotopic labelling methods have been developed including (i) fluorescent tags (1,2,4), (ii) labelling with enzymes (1,2,4,5), and (iii) incorporation of reporter molecules such as biotin, avidin or streptavidin (1,6). Such non‐radioactive dye‐labelling compares because favourably of the rapid and simple techniques used, the availability of many different fluorescent labels and avoidance of radioactivity risk.…”