ChemInform Abstract: SEARCH FOR POTENTIAL ANTICONVULSANT AGENTS. SYNTHESIS OF 2‐PHENYL/METHYL‐3‐(O‐,M‐ OR P‐(BENZIMIDAZOL‐2′‐YL)PHENYL)‐6 OR 6,8‐SUBSTITUTED/UNSUBSTITUTED QUINAZOLIN(3H)‐4‐ONES

Abstract

Wie im Formelschema skizziert, werden die Chinazolinone (IV) synthetisiert.

Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues

“…They were found to be effective as analgesic, anti-inflammatory , antihyperlipidemic (Refaie et al, 2005), antihypertensive (Xue et al, 2004), antihyperglycemic (Ram et al, 2003), and anticancer (Al-Obaid et al, 2009) agents. Specifically, the 3H-quinazolin-4-one derivatives are widely known as anticonvulsant agents as shown in compounds I, II (Misra et al, 1980;Guan et al, 2007). Moreover, few reports concerning the anticonvulsant activity of substituted quinazolinones exemplified by III, IV have been recorded (El-Helby and Wahab, 2003).…”