ChemInform Abstract: SEARCH FOR A NEW METHOD FOR SYNTHESIS OF THE ANALGESIC AGENT ′FENTANYL′

Abstract

Mehrere Varianten der Synthese der Titelverbindung (IX) werden untersucht.

A 5 + 1 Protic Acid Assisted Aza-Pummerer Approach for Synthesis of 4-Chloropiperidines from Homoallylic Amines

“…The reagent HCl•DMPU was prepared as reported in the literature. 12a,b Some of the starting materials and products, 1a, 1e, 25 1b, 1c, 1d, 1f, 2 1e, 26 1k, 1aa, 1ag, 27 1ab, 28 1ae, 29 1ah, 30 3a, 31 3e, 32 3f, 2a, 33 2aa, 5a 2ae, 34 and 2ag, 35 are commercially available or reported compounds, and their spectroscopic data agree well with the reported literature.…”

Fentanyl‐related substance scheduling as an effective drug control strategy

“…The original Janssen method of production, patented in 1964 (U.S. Patent US3141823A), is a process that uses N ‐benzyl piperidone as a starting material. An alternative synthetic method, commonly referred to as the Siegfried method, was published [ 17 , 18 ] and later shared on the internet. This method uses N ‐phenethyl‐4‐piperidone (NPP) and 4‐anilino‐ N ‐phenethylpiperidine (4‐ANPP) as key precursors and was used in clandestine laboratories to illicitly synthesize fentanyl in the early 2000s.…”

Fentanyl-Related Compounds and Derivatives: Current Status and Future Prospects for Pharmaceutical Applications

“…Later, a shorter modified synthesis by the same scheme was proposed, starting directly from 1- (2-phenethyl)piperidin-4-one ( 7 ) (Figure 2) [69]. Another approach, which included a step of hydrogenation of pyridinium salt ( 10 ) has been developed [70].…”