ChemInform Abstract: S‐Acyl Derivatives of Benzothiazole‐2‐thiol: A Convenient Method for the Synthesis of Amides and Carbamates.

Lee, J. H.; Kim, J. D.

doi:10.1002/chin.199742171

Cited by 2 publications

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“…2-Mercaptobenzothiazole (MBT) ( 1 , Figure 1) is an important scaffold known to be associated with several biological activities, and its derivatives are manufactured worldwide for a wide variety of applications. S-acethydrazide hydrazone [1] and S-acyl [2] derivatives of MBT were reported to possess antifungal and antibacterial activities, and were also found to be useful in the leather industry [3]. 2-(Thiocyanomethylthio)benzothiazole [4] is a potential contact fungicide for several economically important crops such as barley, cotton, corn, and wheat.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review

Azam¹

2012

Sci. Pharm.

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2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potential activities.

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Section: Introductionmentioning

confidence: 99%