Abstract:Regioselective Enzymatic Acylation as a Tool for Producing Solution-Phase Combinatorial Libraries. -The flavonoid bergenin (I) is used as suitable model substrate for the title investigations. 11 Enzymes are identified as possible catalysts for selective acylation at the different hydroxyl sites. The strategy leads to a library of 167 selectively acylated derivatives (produced on a robotic workstation in a 96-well plate format).-(MOZHAEV, V. V.; BUDDE, C. L.; RICH, J. O.; USYATINSKY, A. YA.; MICHELS, P. C.; KH… Show more
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