ChemInform Abstract: Regio‐ and Stereoselectivity in Palladium‐Catalyzed Cycloreductions of 1,6‐Enynes in the Presence of Formic Acid or Triethylsilane.

Abstract

2001 ring closure reactions ring closure reactions O 0130 -049Regio-and Stereoselectivity in Palladium-Catalyzed Cycloreductions of 1,6-Enynes in the Presence of Formic Acid or Triethylsilane.-The cyclopalladation of enynes under different conditions is investigated. Thus, the reaction in the presence of formic acid involves cycloalkylpalladium intermediates which undergo β-elimination followed by reduction to the corresponding cycloreduced products, while triethylsilane directly reduces the alkylpalladium intermediate to the corresponding cycloreduced products.