ChemInform Abstract: Reactivity of cis‐Diaminedichloroplatinum(II) (cis‐Platin) Towards Chromium(VI).

Abstract

Reactivity of cis-Diaminedichloroplatinum(II) (cis-Platin) Towards Chromium(VI). -The interactions between the Cr V I compounds (II) and (IV) and cis-compound (I) are studied spectroscopically (IR, UV/Vis, ESR) and the compounds (III) and (V) are isolated. -(STAWINSKA, J.; STASZAK, Z.; JEZIERSKA, J.; CIESLAK-GOLONKA, M.; DASZKIEWICZ, M.; Pol.

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

“…303 On the basis of spectroscopic data, the products were proposed to be a dimetallic heteronuclear Pt−Cr complex and a trimetallic Pt−Cr 2 complex, respectively, with oxo ligands bridging the metal centers (Scheme 21). 303 Similarly, cisplatin was oxidized by iron(III) complexes of the general formula cis-[Fe(bpy′) 2 (CN) 2 ](NO 3 ), where bpy′ is a derivative of 2,2′-bipyridine, to form trinuclear cyanide-bridged complexes (Scheme 21). 304,305 The photochemistry of these complexes was explored, and in some cases the release of aquated cisplatin as a photoproduct occurred, 304,305 thus signifying the potential use of such complexes as photoactivated anticancer agents.…”

“…Analysis by X-ray diffraction revealed a disordered mixture of facial and meridional isomers . Potassium dichromate, K 2 Cr 2 O 7 , and potassium chlorochromate, KCrO 3 Cl, can also oxidize cisplatin . On the basis of spectroscopic data, the products were proposed to be a dimetallic heteronuclear Pt–Cr complex and a trimetallic Pt–Cr 2 complex, respectively, with oxo ligands bridging the metal centers (Scheme ) .…”

“…Potassium dichromate, K 2 Cr 2 O 7 , and potassium chlorochromate, KCrO 3 Cl, can also oxidize cisplatin . On the basis of spectroscopic data, the products were proposed to be a dimetallic heteronuclear Pt–Cr complex and a trimetallic Pt–Cr 2 complex, respectively, with oxo ligands bridging the metal centers (Scheme ) . Similarly, cisplatin was oxidized by iron­(III) complexes of the general formula cis -[Fe­(bpy′) 2 (CN) 2 ]­(NO 3 ), where bpy′ is a derivative of 2,2′-bipyridine, to form trinuclear cyanide-bridged complexes (Scheme ). , The photochemistry of these complexes was explored, and in some cases the release of aquated cisplatin as a photoproduct occurred, , thus signifying the potential use of such complexes as photoactivated anticancer agents.…”