ChemInform Abstract: Reactivity of 4‐Thioxo‐2‐azetidinones.

Abstract

ChemInform Abstract Alkylation of (I) under various conditions demonstrates that charge and thermodynamic control favor in most cases attack on nitrogen to give (IV) rather than (III). Anellation of a five-membered ring to give (VIII) is achieved by 1,3-dipolar cycloaddition of the fumarate (VII) to the azomethine ylide (VI) generated in situ from (IIIa).