ChemInform Abstract: Reactions of Substituted Oxazoles and Thiazoles with Acid Chlorides: Carbon—Carbon Bond Formation Through Cyclic Ketene Acetals.

Abstract

The reaction of 2‐alkylated thiazoles and oxazoles with aryl chlorides is investigated under different conditions.

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

“…This latter compound is then hydrolysed with excess alcoholic base (ii) to yield the desired enol-oxazoline product (5: Scheme 1). Materials such as 4 have found application in the production of other heterocycles [23] and as general synthetic intermediates [24][25][26][27]. A compound of general formula 4 (Scheme 1) has not previously been the subject of study via single crystal X-ray diffraction.…”